Lactate levels and heart failure: causal insights from Mendelian randomization and multi-cohort integrated analyses
Elevated lactate may increase HF risk via impaired cardiac function. NUP50 and other lactate-related genes may regulate HF risk (NUP50 partially via CD20<sup>+</sup> memory B cells), highlighting lactate and its genetic pathways as potential HF prevention/treatment targets.
Authors
- Shijiu Jiang (ORCID: https://orcid.org/0000-0002-8591-5466)
- Shuai Zhou (ORCID: https://orcid.org/0000-0003-3063-6256)
- Yankai Xu
- Kejian Liu (ORCID: https://orcid.org/0000-0002-4532-1583)
- Haiying Hu (ORCID: https://orcid.org/0000-0002-2745-7153)
- R F Dong
Institutions
- Shihezi University (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
Publication Details
- Journal
- Future Science OA
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1080/20565623.2025.2586994
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39