Development of a consensus molecular classifier for pancreatic ductal adenocarcinoma

We developed a robust consensus classifier for PDAC that integrates tumor and stroma features. The classifier is accessible through the R package PDACMOC (PDACMolecularOmniClassifier, https://github.com/pavillos/PDACMOC , https://doi.org/10.5281/zenodo.17161373 ) and a Shiny app ( https://pdacmoc.cnio.es/ ). This classifier offers a biologically grounded framework that integrates existing systems, allows for single-sample classification, and improves prognostic stratification. By enabling subtype-specific therapies and better patient stratification in clinical trials, it can help guide precision medicine and enhance outcomes in PDAC management.