Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia
Our results show that both patient and bacterial factors determine disease presentation and clinical outcomes in TB. They also support the rationale of optimizing treatment regimens against drug-resistant TB with existing drugs based on the specific genetic features of the pathogen. Finally, our results highlight sufD as a possible therapeutic candidate.
Authors
- Nino Maghradze (ORCID: https://orcid.org/0000-0003-1227-1900)
- Zaza Avaliani (ORCID: https://orcid.org/0000-0002-8790-3282)
- Rusudan Aspindzelashvili
- Nestani Tukvadze (ORCID: https://orcid.org/0000-0002-0276-1204)
- Daniela Brites (ORCID: https://orcid.org/0000-0002-8090-2287)
- Levan Jugheli
- Sònia Borrell (ORCID: https://orcid.org/0000-0001-6661-6957)
- Galo Adrián Goig (ORCID: https://orcid.org/0000-0002-4136-6610)
- Teona Avaliani (ORCID: https://orcid.org/0000-0001-8587-7650)
- Chloé Loiseau (ORCID: https://orcid.org/0000-0003-4889-2784)
- Sébastien Gagneux (ORCID: https://orcid.org/0000-0001-7783-9048)
- Kakha Mchedlishvili
- Maia Kipiani (ORCID: https://orcid.org/0000-0002-5913-3858)
- Ana Tsutsunava (ORCID: https://orcid.org/0000-0003-4111-6475)
- Sevda Kalkan
Institutions
- Swiss Tropical and Public Health Institute (CH)
- University of Basel (CH)
- National Center for Tuberculosis and Lung Disease (GE)
- University of Georgia (GE)
- David Tvildiani Medical University (GE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13073-025-01555-0
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung