Genetic regulation of the metabolome differs by sex, Alzheimer's disease stage, and plasma biomarker status
Genetic regulators of the metabolome spanned 66 genes and 12 metabolite classes. Clinically versus biomarker-defined Alzheimer's disease (AD) affects genetic regulators of the metabolome. Most metabolite quantitative trait loci (QTLs) are not shared between males and females.
Authors
- Lawrence S. Honig (ORCID: https://orcid.org/0000-0002-9703-2265)
- Clifton L. Dalgard (ORCID: https://orcid.org/0000-0003-2025-8239)
- Renu Nandakumar
- Diones Rivera Mejía (ORCID: https://orcid.org/0000-0001-5935-8005)
- Martin Medrano
- Saurabh Dubey (ORCID: https://orcid.org/0000-0002-5779-5882)
- Vrinda Kalia (ORCID: https://orcid.org/0000-0003-2244-6663)
- Marielba Zerlin‐Esteves
- Jaclyn M. Eissman (ORCID: https://orcid.org/0000-0001-6439-3999)
- Gary W. Miller (ORCID: https://orcid.org/0000-0001-8984-1284)
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Angel Piriz
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Rafael Lantigua (ORCID: https://orcid.org/0000-0003-4854-7331)
- Min Qiao (ORCID: https://orcid.org/0000-0002-5823-4892)
Institutions
- Uniformed Services University of the Health Sciences (US)
- Pontificia Universidad Católica Madre y Maestra (DO)
- Fundación Ramón Domínguez (ES)
- Universidad Nacional Pedro Henríquez Ureña (DO)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70898
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institute on Aging
- National Center for Advancing Translational Sciences