Impact of <i>RAS</i> / <i>BRAF</i> V600E Mutations on the Tumor Immune Microenvironment in Mismatch Repair–Deficient/Microsatellite Instability Colorectal Cancers
Our data suggest that MSI/dMMR colorectal cancers harboring RASmut are less immunogenic, and the TiME contains a lower inflammatory profile than wild-type or BRAFV600E tumors. Further analysis and validation are required to confirm these findings.
Authors
- Michael J. Overman (ORCID: https://orcid.org/0000-0001-5377-135X)
- Scott Kopetz (ORCID: https://orcid.org/0000-0001-9647-3416)
- Mohamed E. Salem (ORCID: https://orcid.org/0000-0002-3661-6785)
- Josep M. Tabernero (ORCID: https://orcid.org/0000-0002-2495-8139)
- Thomas J. George (ORCID: https://orcid.org/0000-0002-6249-9180)
- Alberto Puccini (ORCID: https://orcid.org/0000-0002-2492-4043)
- David Foureau (ORCID: https://orcid.org/0000-0003-4230-8356)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Frank A. Sinicrope (ORCID: https://orcid.org/0000-0002-2907-1000)
- Jeanne Tie (ORCID: https://orcid.org/0000-0001-9244-2057)
- Elizabeth Mauer (ORCID: https://orcid.org/0009-0001-8033-0696)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Eric Van Cutsem (ORCID: https://orcid.org/0000-0002-6372-1230)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Atrium Health Wake Forest Baptist (US)
- Mayo Clinic (US)
- Humanitas University (IT)
- The University of Texas MD Anderson Cancer Center (US)
- Universitair Ziekenhuis Leuven (BE)
- Peter MacCallum Cancer Centre (AU)
- University of Florida (US)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Levine Cancer Institute (US)
- Istituto Oncologico Veneto (IT)
- Tempus Labs (United States) (US)
- Mayo Clinic in Arizona (US)
- Vall d'Hebron Hospital Universitari (ES)
- Centre de Recherche Saint-Antoine (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- IRCCS Humanitas Research Hospital (IT)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2160
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00