PROM2 exacerbates CCl4-Induced liver fibrosis via NLRP3 inflammasome activation and hepatocyte pyroptosis
PROM2 contributes to liver fibrosis by promoting EMT and activating NLRP3-dependent inflammatory pathways, suggesting it as a potential therapeutic target for liver fibrosis.
Authors
- Jun Hu (ORCID: https://orcid.org/0000-0002-0458-5996)
- Jingyuan Wan (ORCID: https://orcid.org/0000-0002-1773-6474)
- Yan Lin (ORCID: https://orcid.org/0000-0001-8184-6275)
- Ge Kuang (ORCID: https://orcid.org/0000-0003-4197-5069)
- Xia Gong
- Li Zhang (ORCID: https://orcid.org/0000-0001-8718-0216)
- Hao Liu (ORCID: https://orcid.org/0000-0001-6338-4003)
- Jiao Zhang (ORCID: https://orcid.org/0000-0002-6466-6384)
- Hui Du (ORCID: https://orcid.org/0000-0002-7089-9635)
- Ting Wang (ORCID: https://orcid.org/0009-0008-8257-4468)
- Jiashi Guo
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1007/s00018-025-05920-5
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- China Postdoctoral Science Foundation
- Chongqing Medical University