Composition and Functional State of T and NK Cells in the Extramedullary Myeloma Tumor Microenvironment
This study characterizes the TME in EMM lesions and paired BM from patients with multiple myeloma, revealing a high proportion of less cytotoxic CD16- NK cells in EMM tumors and suggesting that direct cell-cell interactions may underlie the CD8+ T-cell exhaustion observed in a subset of these tumors.
Authors
- Ivo Demel (ORCID: https://orcid.org/0000-0002-0518-9581)
- Serafim Nenarokov (ORCID: https://orcid.org/0000-0001-7699-3879)
- Jana Mihályová (ORCID: https://orcid.org/0000-0001-6773-7873)
- Leo Rasche (ORCID: https://orcid.org/0000-0002-9536-9649)
- Gabriela Havlova (ORCID: https://orcid.org/0009-0003-0551-4887)
- Veronika Kapustová (ORCID: https://orcid.org/0000-0002-9937-5667)
- Angela Riedel (ORCID: https://orcid.org/0009-0006-9411-4210)
- Milan Navrátil (ORCID: https://orcid.org/0000-0002-2067-1253)
- Mara John (ORCID: https://orcid.org/0000-0001-7147-405X)
- Helgi van de Velde (ORCID: https://orcid.org/0009-0004-4126-8289)
- Anjana Anilkumar Sithara (ORCID: https://orcid.org/0000-0003-2540-6966)
- Lucie Broskevičová (ORCID: https://orcid.org/0009-0006-1523-2981)
- Juli R. Bagó (ORCID: https://orcid.org/0000-0002-2862-4048)
- Tereza Ševčíková (ORCID: https://orcid.org/0000-0002-8704-0106)
- Michal Kaščák (ORCID: https://orcid.org/0009-0009-1954-9021)
- Michal Šimíček (ORCID: https://orcid.org/0000-0003-2388-2723)
- Moutaz Helal (ORCID: https://orcid.org/0000-0002-9561-1669)
- Jan Vrána (ORCID: https://orcid.org/0000-0001-6171-8516)
- Tomáš Jelı́nek (ORCID: https://orcid.org/0000-0002-5467-9253)
- Hana Plonková (ORCID: https://orcid.org/0000-0002-0543-7987)
- Martin Havel (ORCID: https://orcid.org/0000-0001-7444-5422)
- Ondrej Venglár (ORCID: https://orcid.org/0000-0002-0619-9861)
- Ola Landgren (ORCID: https://orcid.org/0000-0001-6485-4839)
- Sandra Charvátová (ORCID: https://orcid.org/0000-0002-6378-4696)
- Kamlesh Bisht (ORCID: https://orcid.org/0009-0003-3808-924X)
- Tereza Popková (ORCID: https://orcid.org/0000-0001-5885-4218)
- Ludmila Muroňová (ORCID: https://orcid.org/0009-0003-8589-1577)
- Roman Hájek (ORCID: https://orcid.org/0000-0001-6955-6267)
- David Žihala (ORCID: https://orcid.org/0000-0003-4585-0773)
- Daniel Bilek (ORCID: https://orcid.org/0009-0005-1686-0587)
- Hongfang Wang (ORCID: https://orcid.org/0000-0002-1104-1540)
- Eva Radova (ORCID: https://orcid.org/0009-0002-3066-8290)
Institutions
- University of Ostrava (CZ)
- AVEO Oncology (United States) (US)
- University Hospital Ostrava (CZ)
- Institute of Parasitology of the Slovak Academy of Sciences (SK)
- Sanofi (United States) (US)
- Sanofi (Belgium) (BE)
- Universitätsklinikum Würzburg (DE)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0170
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- European Commission
- Deutsche Krebshilfe
- Ostravská Univerzita v Ostravě
- Agentura Pro Zdravotnický Výzkum České Republiky
- National Cancer Institute