Polygenic Risk for Pre‐Eclampsia and the Long‐Term Risk of Incident Hypertension and Cardiovascular Disease: A Population‐Based Cohort Study
Genetic predisposition to PE, as measured by the PE-PRS, is associated with an elevated risk of incident hypertension and ischaemic heart disease in Asian women. These findings suggest the potential utility of the PE-PRS as a complementary tool in assessing individualised hypertension risk in parous women.
Authors
- Sang‐Hyuk Jung (ORCID: https://orcid.org/0000-0003-4116-3327)
- Chamlee Cho (ORCID: https://orcid.org/0009-0002-3155-1932)
- Young Mi Jung (ORCID: https://orcid.org/0000-0001-7877-4450)
- Seung Mi Lee (ORCID: https://orcid.org/0000-0002-2543-0408)
- Injeong Shim (ORCID: https://orcid.org/0000-0002-1001-0945)
- Hong‐Hee Won (ORCID: https://orcid.org/0000-0001-5719-0552)
- Beomsu Kim (ORCID: https://orcid.org/0000-0001-7410-4273)
- E. Choi (ORCID: https://orcid.org/0000-0002-0615-4452)
- Joong Shin Park (ORCID: https://orcid.org/0000-0002-5246-0477)
- Jong Kwan Jun (ORCID: https://orcid.org/0000-0002-0242-1736)
- Jaeyoung Kim (ORCID: https://orcid.org/0000-0001-6983-7907)
- Dokyoon Kim
- C. W. Park
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Seoul National University (KR)
- Kangwon National University (KR)
- Samsung Medical Center (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- National University (SD)
- University of Pennsylvania (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- BJOG An International Journal of Obstetrics & Gynaecology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1111/1471-0528.70072
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Disease Control and Prevention Agency
- National Research Foundation
- Kangwon National University
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Seoul National University Hospital
- Ministry of Education, India
- Ministry of Science and ICT, South Korea
- Institute for Information and Communications Technology Promotion