A Systematic Review of Unichiral Drugs Therapeutic Applications and Pharmaceutical Considerations

Background: Chirality is an essential property of several molecules and a topic on which depend most medicinal chemistry works, that influence the biological activity of drugs . Unichiral drugs, which are defined to be two enantiomers that differ only in the absolute configuration at a single chiral centre, are an important class in the pharmaceutical industry arguably offering superior therapeutic efficacy and lower side effects compared to their racemic counterparts. This systematic review will evaluate the therapeutic uses and pharmaceutical aspects of unichiral drugs by combining the existing literature record to discuss their implications for drug development and clinical use. Methods: Databases were searched using a structured approach according to PRISMA guidelines for systematic searches. This Review comprises 11 original research studies that were identified on the basis of predefined criteria pertaining to unichiral drugs. There were two phases to data extraction, consisting of qualitative and quantitative analyses and quality appraisals referring to the overall credibility of the studies. Result: Unichiral drugs were obtained to be more enantiomerically pure, bioavailable and therapeutically effective than the racemates. Unichiral presentations, especially reduced side effects and subsequently improved patient adherence. Comprehensive cross-study comparisons showed that unichiral drugs display a number of distinct therapeutic benefits, paving the way for discovery of new pharmacotherapies. This review highlights the relevance of unichiral drugs in current medicine and promotes further investigation on their innovation and regulatory pathways. Long-term clinical effects, cost-effectiveness as well as new synthesis method development in order to improve unichiral drugs production should be further studied. Conclusion: Enantiopure drugs represent an attractive frontier of drug development, offering unequivocal advantages over racemic formulations. Clinical evidence to support unichiral strategy was accumulated for improvement of efficacy and reduction of adverse effect. Keywords: Chirality, Pharmacology, Pharmaceutical sciences, Drug­therapy interaction, Drug development, Therapeutic applications, Enantiomeric purity, Unichiral drugs, Bioavailability, Clinical efficacy