Neutrophil Extracellular Traps Activate Meningeal Fibroblast to Aggravate Subarachnoid Fibrosis in Kaolin‐Induced Hydrocephalus in Rats
NETs aggravate subarachnoid fibrosis to promote hydrocephalus via stimulating the proliferation and differentiation of meningeal fibroblasts, and restricting NETs significantly prevents the development of hydrocephalus through attenuating subarachnoid fibrosis. It indicates that NETs might be a promising potential target for clinical hydrocephalus treatment.
Authors
- Binyuan Xiong
- Zhi Chen (ORCID: https://orcid.org/0000-0002-8404-4937)
- Liang Tan (ORCID: https://orcid.org/0000-0002-6916-2134)
- Lingxia Min
- Peiwen Guo (ORCID: https://orcid.org/0000-0001-8029-9476)
- Shengyan Liu (ORCID: https://orcid.org/0000-0003-0582-7085)
- Jingyu Chen (ORCID: https://orcid.org/0000-0002-2127-1788)
- Qiang Zhang (ORCID: https://orcid.org/0009-0001-9418-8520)
- Liang Liang (ORCID: https://orcid.org/0000-0002-5072-423X)
- Zhou Feng (ORCID: https://orcid.org/0000-0003-4196-5805)
- Chao Ma (ORCID: https://orcid.org/0000-0003-3930-9358)
- Jingming Hou (ORCID: https://orcid.org/0000-0002-4991-7587)
Institutions
- Army Medical University (CN)
- Zunyi Medical University (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- Chongqing City Mental Health Center (CN)
- People's Liberation Army 401 Hospital (CN)
- Southwest Hospital (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/iid3.70268
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Army Medical University