Serum Biomarkers Linked to Disease Activity, Severity, and Methylprednisolone Response in Graves’ Orbitopathy: A Proteomic Study
Serum VEGF-A is increased in IVMP non-responders and thus may be a biomarker for predicting treatment response in GO. Furthermore, GO shares immunopathobiological features with IOI and IgG4-ROD.
Authors
- Ben F.J. Goudsmit (ORCID: https://orcid.org/0000-0003-0768-7688)
- Ronald O. B. de Keizer
- Gijsbert J. Hötte (ORCID: https://orcid.org/0000-0003-3916-0012)
- W. Edward Visser (ORCID: https://orcid.org/0000-0002-5248-863X)
- Dion Paridaens (ORCID: https://orcid.org/0000-0001-6762-3614)
- P. Martijn Kolijn (ORCID: https://orcid.org/0000-0002-2139-637X)
- Willem A. Dik (ORCID: https://orcid.org/0000-0001-5235-3156)
- Maaike de Bie
- Sigrid M. A. Swagemakers
- Peter J. van der Spek
- P. Martin van Hagen
Institutions
- Erasmus MC (NL)
- Medisch Centrum Haaglanden (NL)
- Rotterdam Eye Hospital (NL)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1167/iovs.66.14.32
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stichting Steunfonds Uitzicht
- ZonMw
- Oogfonds
- Stichting Wetenschappelijk Onderzoek Oogziekenhuis