Development of the rationale of a personalized cancer vaccine based on the in situ vaccine effect of radiotherapy: a mechanistic study of the POLARSTAR trial
Radiation-elicited tumor cell death exhibited an in situ vaccine effect to potentiate immune checkpoint blockade, and autologous tumor cells irradiated in vitro at a sterilization level may serve as a candidate source of immunogen for personalized therapeutical cancer vaccine.
Authors
- Liping Duan (ORCID: https://orcid.org/0000-0001-6886-6888)
- Xinzhi Liu (ORCID: https://orcid.org/0000-0003-3572-2807)
- Kai Pang
- Peilin Sun
- Guangyong Chen (ORCID: https://orcid.org/0000-0002-5892-8608)
- Pengfei Zhao (ORCID: https://orcid.org/0000-0001-7300-1571)
- Shun Cao
- Yingchi Yang (ORCID: https://orcid.org/0000-0002-9126-3281)
- Huajing Yu (ORCID: https://orcid.org/0000-0002-8028-6146)
- Yongjie Huang
- Yang Gao
- Zhongtao Zhang
- Dan Yang (ORCID: https://orcid.org/0000-0001-9984-7225)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University Third Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s00262-025-04229-3
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00