Genetic homocysteine risk shapes cardiocerebral structure and multimorbidity through age- and sex-specific mechanisms: a UK Biobank study
Our findings suggest that genetically determined Hcy levels impact cardiocerebral structure in a sex- and age-dependent manner, contributing to disease risk. Structural imaging phenotypes offer potential as early mediators. The dietary effects on disease risk may involve pathways independent of Hcy modulation.
Authors
- Chenjie Feng (ORCID: https://orcid.org/0000-0001-7898-9291)
- Peng Zhang (ORCID: https://orcid.org/0000-0001-7721-2675)
- Y. M. Ma (ORCID: https://orcid.org/0000-0002-1380-0088)
- Tian Zhang (ORCID: https://orcid.org/0000-0002-0538-1071)
- Yu Xia Zhao (ORCID: https://orcid.org/0000-0002-0958-0350)
Institutions
- Ningxia Medical University (CN)
- Ningxia Center for Diseases Prevention and Control (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fnut.2025.1637592
- Citations
- 1
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- National Natural Science Foundation of China
- Ningxia Medical University
- Natural Science Foundation of Ningxia Province