Volumetric 3D Printing and Melt‐Electrowriting to Fabricate Implantable Reinforced Cardiac Tissue Patches (Adv. Mater. 45/2025)
Implantable Reinforced Cardiac Tissue Patches In their Research Article (DOI: 10.1002/adma.202504765), Lewis S. Jones, Robert K. Katzschmann, and co-workers introduce the reinforced cardiac patch (RCPatch) for intraventricular myocardial repair. The multimaterial design integrates a stiffness-tuned, cardiomyocyte-infiltrated 3D metamaterial with a hydrogel-filled melt-electrowritten mesh. In a large-animal model, the RCPatch sealed a myocardial defect, prevented bleeding, and restored hemodynamic stability, providing a surgically implantable and regenerative platform for cardiac repair.
Authors
- Miriam Weisskopf (ORCID: https://orcid.org/0000-0001-6012-3051)
- Omer Dzemali (ORCID: https://orcid.org/0000-0001-7910-5152)
- Lewis S. Jones (ORCID: https://orcid.org/0000-0003-0381-2285)
- Melanie Generali (ORCID: https://orcid.org/0000-0001-8396-3256)
- Héctor Rodríguez Cetina Biefer (ORCID: https://orcid.org/0000-0002-5855-8993)
- Robert K. Katzschmann (ORCID: https://orcid.org/0000-0001-7143-7259)
- Quinten Thijssen (ORCID: https://orcid.org/0000-0003-3428-7946)
- Li Zheng (ORCID: https://orcid.org/0000-0002-2488-3237)
- Debora Meier (ORCID: https://orcid.org/0000-0002-4217-2607)
- Manuel Mekkattu
- August Böck
- Alessio Amicone
- Dennis Zorndt
Institutions
- University of Zurich (CH)
- Triemli Hospital (CH)
- Ghent University (BE)
- ETH Zurich (CH)
- Institute for Biomedical Engineering (CH)
- Swiss Institute for Regenerative Medicine (CH)
- University Hospital of Zurich (CH)
- Institute of Macromolecular Chemistry (UA)
Publication Details
- Journal
- Advanced Materials
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/adma.71188
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00