Modelling APOL1-mediated kidney inflammation and fibrosis using a partially reprogrammed urine-derived SIX2-positive renal progenitor cell line
Given their robust proliferation capacity, UM30-OSN cells represent a valuable additional model for investigating kidney-associated diseases such the contribution of APOL1 high-risk variants to kidney injury and fibrosis.
Authors
- Wasco Wruck (ORCID: https://orcid.org/0000-0002-9153-7051)
- Kate Bramham (ORCID: https://orcid.org/0000-0002-6272-7921)
- Chantelle Thimm (ORCID: https://orcid.org/0009-0001-5019-3651)
- Rosanne Mack
- Dalvir Kular (ORCID: https://orcid.org/0000-0001-8489-7158)
- James Adjaye (ORCID: https://orcid.org/0000-0002-6075-6761)
- Ania Koziell (ORCID: https://orcid.org/0000-0003-4882-0246)
- Osmond Adjei-Aruna
Institutions
- King's College London (GB)
- National Institute of Child Health (HU)
- Institute of Child Health (GR)
- Capital Region of Denmark (DK)
- Heinrich Heine University Düsseldorf (DE)
- University College London (GB)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13287-025-04710-x
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00