Bacillus subtilis as cell factory for enhanced production of the biopolymer precursor pyridine-2,6-dicarboxylic acid
This study demonstrates the potential of engineered B. subtilis BSDYvyDVF-gerE as an efficient cell factory for sustainable DPA biosynthesis. In addition, it identifies key challenges in DPA production, including synthesis efficiency (regulation of key enzyme expression) and transport (intracellular-to-extracellular export), and proposes corresponding solutions.
Authors
- Stanley Brul (ORCID: https://orcid.org/0000-0001-5706-8768)
- Jeroen Hugenholtz (ORCID: https://orcid.org/0000-0002-3274-0092)
- Taichi Chen (ORCID: https://orcid.org/0000-0002-0823-7032)
- Haris Uzunovic
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Northwest University (CN)
- Radboud Institute for Molecular Life Sciences (NL)
- Huisarts en Wetenschap (NL)
- Stichting Wetenschappelijk Onderzoek Verkeersveiligheid (NL)
- Amsterdam University of Applied Sciences (NL)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12934-025-02859-x
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council