Temporal dynamics of ADSC therapy in skin fibrosis: unraveling the roles of ROS/NF-κB/TSG-6 signaling axis
ADSCs resolve skin fibrosis through a biphasic mechanism involving initial adaptation and subsequent immunomodulation/ECM remodeling, centrally governed by a ROS-NF-κB-TSG-6 axis. TSG-6 is the critical downstream effector, disrupting the TGF-β/Smad pathway and inflammation. This study identifies TSG-6 as a key therapeutic mediator and a potential biomarker for optimizing ADSC-based therapies for fibrotic skin disorders.
Authors
- Nanze Yu (ORCID: https://orcid.org/0000-0003-4312-6036)
- Songlu Tseng (ORCID: https://orcid.org/0009-0000-7130-4421)
- Xuda Ma
- Liquan Wang (ORCID: https://orcid.org/0000-0002-7942-0125)
- Tianhao Li (ORCID: https://orcid.org/0000-0001-5716-8320)
- Jiuzuo Huang (ORCID: https://orcid.org/0000-0002-0458-9006)
- Xiao Long
- Jieyu Xiang (ORCID: https://orcid.org/0000-0003-3722-4094)
- Ziming Li (ORCID: https://orcid.org/0009-0009-5351-2302)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13287-025-04746-z
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Peking Union Medical College