Single-cell RNA sequencing and in vitro validation reveal risankizumab induces anti-inflammatory macrophage polarization in psoriasis
This study reveals that risankizumab exerts its anti-inflammatory effects by inhibiting M1-type and promoting M2-type macrophage polarization, thereby elucidating its key mechanism for treating psoriasis and providing theoretical support for novel immunotherapy targets.
Authors
- Guanghui Gao (ORCID: https://orcid.org/0000-0003-2947-2311)
- Wen Sun (ORCID: https://orcid.org/0000-0003-4253-8047)
- Jiyuan Zheng (ORCID: https://orcid.org/0000-0003-3735-1309)
- Linzi Li
- Yuan Yuan (ORCID: https://orcid.org/0000-0003-0907-9934)
- Lihong Yang (ORCID: https://orcid.org/0000-0001-8753-3114)
- Jing Liu (ORCID: https://orcid.org/0000-0002-0224-1700)
- Ting Tan (ORCID: https://orcid.org/0009-0006-6716-0975)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Minzu University of China (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Jingzhou Central Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s40001-025-03346-0
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Health Commission of Hubei Province