TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway
In lens cells, the eHSP90α's secretion undertakes secretory autophagy pathway through interacting with TRIM16 and SEC22B. TGF-β2 elevates eHSP90α secretion through upregulating secretory autophagy pathway, which in turn promote TGF-β2-induced lens epithelial cells' differentiation to lens fiber cells.
Authors
- Xiumei Kong
- Yanzhong Hu (ORCID: https://orcid.org/0000-0002-8269-4629)
- Fengling Yuan
- Hongmei Mu
- Hongwei Tian
- Weikai Guo (ORCID: https://orcid.org/0000-0001-9361-3903)
- Xiukun Cui (ORCID: https://orcid.org/0000-0003-2555-3413)
- Shuxin Huang (ORCID: https://orcid.org/0000-0002-0634-4870)
- Mingli Wang (ORCID: https://orcid.org/0000-0002-0343-0343)
- Junmin Li (ORCID: https://orcid.org/0000-0003-0775-0878)
- Tong Xie
- Hui Li (ORCID: https://orcid.org/0000-0003-1568-0144)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-2716-7313)
- Dongzhe Zhang (ORCID: https://orcid.org/0009-0002-2908-4570)
- Mengyun Liu (ORCID: https://orcid.org/0000-0002-7796-1884)
- Jing Li (ORCID: https://orcid.org/0000-0001-6640-0152)
- Khan Iqbal Nawaz
Institutions
- Henan University (CN)
- Kaifeng University (CN)
- Henan Provincial Eye Hospital (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12964-025-02493-5
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00