Absence of complement terminal pathway activity in C6-deficient mice prolongs survival in a mouse model of severe malarial infection
We show that complement terminal pathway activation exacerbates organ injuries and thrombocytopenia associated with P. bergei infection, contributing to rapid progression to death in the model. Inhibition of terminal pathway activation in human malarial infections using available drugs might slow progression to organ failure, extending the window of opportunity for the effective use of anti-malarial medicines.
Authors
- Tomoaki Kamiya (ORCID: https://orcid.org/0000-0001-7261-6611)
- Tamio Ohno (ORCID: https://orcid.org/0009-0005-9248-2880)
- Masashi Mizuno (ORCID: https://orcid.org/0000-0003-3235-6880)
- Shoichi Maruyama (ORCID: https://orcid.org/0000-0002-8858-632X)
- Masatoshi Ishigami (ORCID: https://orcid.org/0000-0003-0938-631X)
- Sosuke Fukui
- Yuki Miyasaka (ORCID: https://orcid.org/0009-0007-4454-5327)
- Hangsoo Kim (ORCID: https://orcid.org/0009-0009-9248-3356)
- B. Paul Morgan (ORCID: https://orcid.org/0000-0003-4075-7676)
- Yasuhiro Suzuki (ORCID: https://orcid.org/0000-0001-9046-5466)
- Masatoshi Inoue (ORCID: https://orcid.org/0000-0002-3024-0422)
- Timothy R. Hughes
Institutions
- Cardiff University (GB)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.imbio.2025.153140
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00