Metformin protects against cyclophosphamide-induced ovarian fibrosis by MIF/CD74-mediated macrophage polarization
These findings highlight a novel mechanism by which metformin alleviates CTX-induced ovarian fibrosis by targeting the MIF/CD74 axis to reprogram macrophage-fibroblast communication, suggesting metformin as a protective adjuvant to improve ovarian health during chemotherapy.
Authors
- Minghua Wang (ORCID: https://orcid.org/0000-0003-2505-1130)
- Jingling Li (ORCID: https://orcid.org/0000-0002-1498-0260)
- Gendie E. Lash (ORCID: https://orcid.org/0000-0002-3606-1361)
- Ping Nie (ORCID: https://orcid.org/0000-0002-8640-8685)
- Bo Yao
- Ping Li (ORCID: https://orcid.org/0000-0003-3473-6553)
- Zhejun Zhang
- Bihui Guo (ORCID: https://orcid.org/0009-0000-4445-3018)
Institutions
- Jinan University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Huizhou Central People's Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shenzhen Second People's Hospital (CN)
- Guangzhou Medical University (CN)
- Huizhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12967-025-07294-5
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00