Benzodiazepines versus non-benzodiazepine antiseizure medications as first-line agents for status epilepticus: analysis of real word data from a 9-years prospective cohort
The use of non-BDZ first-line treatment was found to be frequent, approaching 25%. Our propensity-score matching analysis shows that in some patients, mainly with NCSE, the overall prognosis of SE was not affected by first-line use of non-BDZ drugs. In these cases, SE prognosis might only be partially dependent on the first medications administered and could be more influenced by other biological variables.
Authors
- Gianni Turcato (ORCID: https://orcid.org/0000-0002-8890-4113)
- Stefano Meletti (ORCID: https://orcid.org/0000-0003-0334-539X)
- Simona Lattanzi (ORCID: https://orcid.org/0000-0001-8748-0083)
- Francesco Brigo (ORCID: https://orcid.org/0000-0003-0928-1577)
- Giada Giovannini (ORCID: https://orcid.org/0000-0002-3585-5872)
- Lisa Taruffi (ORCID: https://orcid.org/0009-0004-6770-777X)
- Niccolò Orlandi (ORCID: https://orcid.org/0000-0002-5717-7363)
- Arian Zaboli (ORCID: https://orcid.org/0000-0002-4204-8884)
- Margherita Burani (ORCID: https://orcid.org/0009-0004-0981-4788)
- Leonardo Affronte
Institutions
- University of Modena and Reggio Emilia (IT)
- Marche Polytechnic University (IT)
- Eurac Research (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Ospedale Sant Antonio (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fneur.2025.1681483
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università Degli Studi di Modena e Reggio Emila
- Dipartimenti di Eccellenza
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Regione Emilia-Romagna