DAPK1 identified as a novel biomarker for colorectal cancer liver metastasis
By combining machine learning and multi-omics bioinformatics approaches, we identified DAPK1 as a novel biomarker for CRC liver metastasis, which has potential implications for prognosis and therapeutic targeting. These findings highlight DAPK1 as a critical driver of metastatic progression and provide a theoretical foundation for the treatment of CRC.
Authors
- Bo Pan (ORCID: https://orcid.org/0000-0002-0984-2058)
- Zhen Feng (ORCID: https://orcid.org/0000-0003-1281-4522)
- Yina Gao
- Qianshi Zhang (ORCID: https://orcid.org/0000-0002-3336-9934)
- Zhenyu Zhang (ORCID: https://orcid.org/0000-0001-6655-053X)
- Yinan Zhang (ORCID: https://orcid.org/0000-0001-9934-4564)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12935-025-04037-w
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Dalian Medical University