Corneal Amiodarone Deposition and Its Implications for Autologous Serum Eye Drop Therapy: A Case Report

Corneal toxicity and deposits can develop from a variety of systemic and topical medications used in ophthalmic and non-ophthalmic care. We report a case of a 69-year-old man with dry eye syndrome on long-term amiodarone therapy who developed bilateral corneal verticillata shortly after initiating autologous serum eye drops (ASEDs). Despite improvement in epithelial healing, the new deposits raised concern for exacerbation of amiodarone-related corneal toxicity, possibly influenced by ASEDs. This case underscores the potential interaction between systemic therapy and ASEDs, highlighting the importance of careful monitoring in patients with ocular surface disease receiving medications known to cause ocular complications.