Neuronal differentiation and tissue engineering strategies for central neurous system injury repair

Abstract Central nervous system (CNS) injury can cause devastating neurological dysfunction in patients, permanently impairing their ability to take care of themselves and reducing their quality of life. At present, neural tissue engineering is the most promising way to treat this disease. However, there are still many challenges and obstacles in the process of correctly structuring tissue engineering. The successful development of tissue engineering relies on three key components: biological scaffold materials, seed cells, and various growth factors. In summary, this review provides a systematic analysis of scaffold materials differentiation strategies for inducing diverse stem cells into neuro‐like cells. The synthesized findings not only accelerate regenerative medicine approaches but also provide the critical solutions for CNS injury treatment and advance therapeutic development, offering important references for future research and clinical translation.