Investigations into the basal neural-like properties of dental pulp stem cells reveal they possess a functional type 2 muscarinic receptor which regulates quiescence
DPSCs exhibit cholinoceptive properties, and activation of the m2AChR engages the MAPK/ERK pathway and is associated with a reversible cell-cycle arrest consistent with a quiescent-like state, without affecting viability or pluripotency. These data support the m2AChR as a putative target for manipulating DPSC behaviour and transient quiescence in future regenerative applications.
Authors
- Christopher J. Nile (ORCID: https://orcid.org/0000-0001-8218-2167)
- William McLean (ORCID: https://orcid.org/0000-0003-4942-7075)
- Manu Verma (ORCID: https://orcid.org/0000-0002-5689-2808)
- OthmanM Baradwan
- Saeed M. Alqahtani (ORCID: https://orcid.org/0000-0001-9669-2408)
- Anna Gibbs (ORCID: https://orcid.org/0000-0002-9080-965X)
- Mushari Alonazi
- K. Jubiar
Institutions
- Jouf University (SA)
- Newcastle Dental Hospital (GB)
- University of Glasgow (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13287-025-04730-7
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00