THBS1high macrophages promote aortic aneurysm formation by orchestrating an inflammatory and smooth muscle cell phenotypic transition program in vascular Behçet’s disease
Overall, our findings underscore the pivotal role of THBS1<sup>high</sup> macrophages in vascular degeneration, highlighting the therapeutic potential of anti-TNF therapy in VBD and the THBS1's potential as a biomarker for clinical evaluation.
Authors
- Yuanyuan Wei (ORCID: https://orcid.org/0000-0003-0635-6879)
- Dan Meng (ORCID: https://orcid.org/0000-0001-8588-0235)
- Lindi Jiang (ORCID: https://orcid.org/0009-0001-6428-7579)
- Jun Hou (ORCID: https://orcid.org/0000-0002-4387-8222)
- Xianting Sun
- Jun Li (ORCID: https://orcid.org/0000-0002-7308-6576)
- Xiufang Kong (ORCID: https://orcid.org/0000-0002-4326-6517)
- Kefang Guo (ORCID: https://orcid.org/0000-0001-6622-2587)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12916-025-04434-y
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00