Mechanism of methyltransferase METTL14 mediating m6A modification and regulating SIRT5 expression to promote ferroptosis and repress gastric cancer progression
METTL14 stabilizes SIRT5 mRNA via m6A modification, upregulating SIRT5 expression and inducing ferroptosis, thereby inhibiting GC progression.
Authors
- Kaiqing Guo (ORCID: https://orcid.org/0009-0006-9152-5743)
- Zhe Bai
- Yi Jia
- Haoruo Zhang (ORCID: https://orcid.org/0009-0009-8317-5394)
Institutions
- Shanxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s40001-025-03236-5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00