Associations of longitudinal trajectories of triglyceride-glucose index combined with classical and novel obesity indices and cardiovascular disease: evidence from a nationwide prospective cohort study in China
In this cohort study, the longitudinal trajectories of TyG and its obesity derivatives were closely associated with CVD. Comparatively, the combinations of TyG with classical obesity index WC and novel obesity index CVAI (TyG-WC and TyG-CVAI) exhibited superior performance for CVD risk assessment, with this risk primarily driven by obesity and triglycerides.
Authors
- Yang Zou (ORCID: https://orcid.org/0000-0002-1320-004X)
- Zhiyu Xiong
- Guobo Xie (ORCID: https://orcid.org/0000-0002-5020-4920)
- Shiming He
- Qun Wang (ORCID: https://orcid.org/0000-0003-4853-1727)
- Wei Wang (ORCID: https://orcid.org/0000-0003-1005-059X)
- Shuhua Zhang (ORCID: https://orcid.org/0000-0002-5748-0637)
- Lin Xie (ORCID: https://orcid.org/0000-0002-2538-347X)
- Xue Li (ORCID: https://orcid.org/0009-0009-2904-9004)
- Hengcheng Lu (ORCID: https://orcid.org/0009-0003-5110-0829)
- Chao Wang (ORCID: https://orcid.org/0000-0001-7885-9673)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- West Anhui University (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12933-025-02972-6
- Citations
- 9
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 11.65
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Health Commission of Jiangxi Province