Genome-wide association study identifies three PNPLA3/SAMM50 SNPs associated with HCC development in non-viral liver disease
Variants in the <i>PNPLA3/SAMM50</i> locus were significantly associated with hepatocellular carcinoma (HCC) risk in individuals seronegative for HBsAg and anti-HCV. The stepwise increase in HCC risk with higher numbers of risk alleles suggests their potential utility as biomarkers to identify high-risk individuals without a history of chronic hepatitis B or C virus infection. These findings provide a foundation for genetic risk stratification and precision prevention strategies in populations where non-viral etiologies of HCC are becoming increasingly important.
Authors
- Tung‐Hung Su (ORCID: https://orcid.org/0000-0002-6747-7941)
- Shun‐Fa Yang (ORCID: https://orcid.org/0000-0002-0365-7927)
- Yen-Chun Peng (ORCID: https://orcid.org/0000-0002-8993-3039)
- See‐Tong Pang (ORCID: https://orcid.org/0000-0002-2064-0828)
- Chien‐Jen Chen
- Tsai-Hsuan Yang (ORCID: https://orcid.org/0009-0003-5932-611X)
- Chih‐Yang Huang (ORCID: https://orcid.org/0000-0003-2347-0411)
- Ming‐Chih Hou (ORCID: https://orcid.org/0000-0002-4886-0718)
- Hwai‐I Yang (ORCID: https://orcid.org/0000-0002-3433-942X)
- Peng‐Ju Huang
- I‐Ming Chen (ORCID: https://orcid.org/0000-0002-4831-3781)
- Fen-Fang Chen
- Jia‐Horng Kao (ORCID: https://orcid.org/0000-0002-2442-7952)
- Ming‐Lung Yu (ORCID: https://orcid.org/0000-0001-8145-1900)
- Mei‐Hsuan Lee (ORCID: https://orcid.org/0000-0002-0222-2251)
- Yi-Ting Chen (ORCID: https://orcid.org/0000-0002-6694-7729)
- Ya‐Hsuan Chang (ORCID: https://orcid.org/0000-0002-0743-4819)
- Szu‐Ching Yin
- Hsuan‐Yu Chen (ORCID: https://orcid.org/0000-0003-0358-9132)
- Xia-Rong Liu
- S. Lee
Institutions
- National Sun Yat-sen University (TW)
- Asia University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- National Health Research Institutes (TW)
- National Taiwan University (TW)
- Chang Gung University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- Genomics Research Center, Academia Sinica (TW)
- Taichung Veterans General Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- China Medical University Hospital (TW)
- National Taiwan University Hospital (TW)
- Koo Foundation Sun Yat-Sen Cancer Center (TW)
- Institute of Statistical Science, Academia Sinica (TW)
- Kaohsiung Municipal Hsiao-Kang Hospital (TW)
- Changhua Christian Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101673
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35