Impact of oral anaerobic bacteria on the tumor immune microenvironment and prognosis of oral cancer
This is the first study to show a direct relationship between intratumoral anaerobic bacterial predominance and CD8⁺ T cell exhaustion in OSCC, suggesting a microbiota-dependent mechanism of immune dysfunction and disease progression. The bacteria scoring system has potential as a prognostic marker and guide for microbiota-targeted therapies to enhance anti-tumor immunity.
Authors
- Hisashi Wada (ORCID: https://orcid.org/0000-0002-5444-6193)
- Atsunari Kawashima (ORCID: https://orcid.org/0000-0001-9369-4264)
- Azumi Ueyama (ORCID: https://orcid.org/0009-0007-1352-761X)
- Kana Kashima
- Narikazu Uzawa (ORCID: https://orcid.org/0000-0001-5390-6875)
- Takuro Saito (ORCID: https://orcid.org/0000-0002-1733-5064)
- Hitomi Kajikawa
Institutions
- Osaka City University (JP)
- Shionogi (Japan) (JP)
- Futaba (Japan) (JP)
- Osaka Dental University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12967-025-07189-5
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61