Mass spectrometry-based untargeted metabolomics study of polycystic ovary syndrome
This study demonstrates distinct alterations in lipid and amino acid metabolism in PCOS and highlights the accumulation of exogenous molecules, including endocrine disruptors, in patient serum. By integrating metabolomic profiling with clinical phenotyping, our findings provide novel insights into PCOS pathophysiology and suggest potential serum biomarkers that may support early diagnosis and personalized therapeutic approaches.
Authors
- Ayşe Zehra Gül (ORCID: https://orcid.org/0000-0002-9223-1054)
- Şahabettin Selek (ORCID: https://orcid.org/0000-0003-1235-3957)
- Ömer Faruk Özer (ORCID: https://orcid.org/0000-0002-9034-4805)
- Havva Sevde İşlek (ORCID: https://orcid.org/0000-0002-9998-4948)
- Metin Demirel (ORCID: https://orcid.org/0000-0003-4810-6771)
- Seda ATEŞ (ORCID: https://orcid.org/0000-0001-9244-6752)
- Ayşe Zeynep İbrahimoğlu (ORCID: https://orcid.org/0000-0003-3235-4658)
- Merve İbrahimoğlu (ORCID: https://orcid.org/0000-0001-8168-9505)
Institutions
- Bezmiâlem Vakıf Üniversitesi (TR)
- Education Training And Research (US)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13048-025-01842-9
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bezmialem Vakıf Üniversitesi