MicroRNA-142 improves IL1RAP CAR-T cell activity in acute myeloid leukemia
We have identified a potentially novel strategy to enhance CAR-T cell persistence and efficacy in AML by counteracting a leukemia-induced, microRNA-deficiency mediated mechanism of immune suppression.
Authors
- John C. Williams (ORCID: https://orcid.org/0000-0002-0522-384X)
- Le Xuan Truong Nguyen (ORCID: https://orcid.org/0000-0001-5464-0861)
- Guido Marcucci
- Fang Chen (ORCID: https://orcid.org/0000-0002-7616-7224)
- Lucy Ghoda (ORCID: https://orcid.org/0000-0002-8212-3586)
- Kaito Harada (ORCID: https://orcid.org/0000-0002-8462-7550)
- Ashlie Munoz (ORCID: https://orcid.org/0000-0001-8468-5438)
- Miso Park (ORCID: https://orcid.org/0000-0002-9792-9574)
- Idoroenyi Amanam (ORCID: https://orcid.org/0000-0003-4819-4628)
- Yi Zhang (ORCID: https://orcid.org/0000-0003-3419-2461)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-4371-4746)
- Jianjun Chen (ORCID: https://orcid.org/0000-0003-3749-2902)
- Dandan Zhao (ORCID: https://orcid.org/0000-0002-0723-7428)
- Bea Parcutela
- Yead Jewel
- Stephen J. Forman
- Yongfang Xu
- Yile Zhou
Institutions
- City Of Hope National Medical Center (US)
- Tokai University (JP)
- City of Hope (US)
- Tokai University Hospital (JP)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Beckman Research Institute
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13045-025-01755-6
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comprehensive Cancer Center, City of Hope
- National Cancer Institute