Global mapping of RNA N6-methyladenosine (m6A) in human subcutaneous and visceral adipose tissue reveals novel targets that correlate with clinical variables of obesity
We identify a catalogue of novel targets showing adipose tissue depot specific m<sup>6</sup>A methylation, with potential as biomarkers in metabolic disease. Our findings underscore the regulatory role of m<sup>6</sup>A in obesity and provide valuable insights for future research. The datasets generated represent a significant resource for further insight in adipose tissue biology and its implications for metabolic health.
Authors
- Torunn Rønningen (ORCID: https://orcid.org/0009-0002-2452-0871)
- Yvonne Böttcher
- Marius Svanevik (ORCID: https://orcid.org/0000-0003-4303-5935)
- Akın Çayır
- Tina Visnovska (ORCID: https://orcid.org/0000-0003-4920-9756)
- Jon Kristinsson
- Mai Britt Dahl (ORCID: https://orcid.org/0009-0002-6085-5337)
- Tone Tannæs (ORCID: https://orcid.org/0000-0002-4779-2303)
- Jens Kristoffer Hertel (ORCID: https://orcid.org/0000-0002-8693-7018)
- Housheng Hansen He (ORCID: https://orcid.org/0000-0003-2898-3363)
- Tom Mala (ORCID: https://orcid.org/0000-0003-3058-4775)
- Lars la Cour Poulsen (ORCID: https://orcid.org/0000-0001-5406-3945)
- Matthias Blüher (ORCID: https://orcid.org/0000-0003-0208-2065)
- Junbai Wang (ORCID: https://orcid.org/0000-0001-5505-5613)
- Jøran Hjelmesæth (ORCID: https://orcid.org/0000-0002-1995-0562)
- Yong Zeng (ORCID: https://orcid.org/0000-0001-5719-1272)
- Tone Gretland Valderhaug (ORCID: https://orcid.org/0000-0002-9953-7865)
- Stina Ingrid Alice Svensson
Institutions
- Oslo University Hospital (NO)
- University Health Network (CA)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Sykehuset i Vestfold (NO)
- Princess Margaret Cancer Centre (CA)
- Helmholtz Zentrum München (DE)
- University Hospital Leipzig (DE)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s40364-025-00857-0
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Norwegian Sequencing Centre
- Universitetet i Oslo
- Akershus Universitetssykehus
- Helse Sør-Øst RHF