Neurogenic inducers inhibit the proliferation of pancreatic cancer by promoting tumor cell transdifferentiation
Our findings demonstrate that pancreatic cancer cells can be induced to transdifferentiate through NeuroD1 activation or pharmacological induction, suggesting a potential therapeutic strategy to mitigate malignancy by reprogramming tumor cells into less aggressive states.
Authors
- Kaizhou Jin (ORCID: https://orcid.org/0000-0002-0844-826X)
- Duancheng Guo (ORCID: https://orcid.org/0000-0002-5915-7390)
- Hao Li (ORCID: https://orcid.org/0000-0002-8978-0247)
- Jianhui Yang (ORCID: https://orcid.org/0000-0002-8710-1722)
- Qinglin Fei (ORCID: https://orcid.org/0000-0002-4170-2215)
- Saimeng Shi
- Ji Xu (ORCID: https://orcid.org/0000-0002-6560-0491)
- Wenxia Peng
- Long‐Yun Ye (ORCID: https://orcid.org/0009-0005-7388-9212)
- Mengdi Yang (ORCID: https://orcid.org/0009-0007-9315-0604)
- Xichun Hu (ORCID: https://orcid.org/0000-0002-2157-2695)
- Weiding Wu
Institutions
- Shanghai Medical College of Fudan University (CN)
- East China University of Science and Technology (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13046-025-03563-9
- Citations
- 1
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 1.47