The Role of Creatine in Enhancing Bone Health Among Postmenopausal Women

Given the high popularity of creatine as a dietary supplement, its pleiotropiceffects, and its well-established safety profile, it is worth considering as an adjuncttherapy for osteoporosis—a condition that predominantly affects postmenopausalwomen due to hormonal changes, particularly a decline in estrogen levels—and hasbecome a silent epidemic of the 21st century. Creatine may indirectly enhance musclemass and strength, leading to increased mechanical stress on bones, and some studiessuggest that creatine might also directly influence osteoblast activity and bonemetabolism, potentially promoting bone formation. These direct and indirectmechanisms may improve bone health in at-risk women, reducing the risk of falls andfractures and ultimately contributing to a better quality of life. This research exploresthe effects of creatine on bone remodeling, metabolic activity, resistance trainingperformance, and its potential anti-inflammatory properties in the context of skeletalhealth maintenance. It also examines appropriate creatine dosing in older adults—whichtypically does not require a loading phase—and evaluates the safety of creatine use inaging women.