iPSCs derived sEVs ameliorate NK cell senescence by targeting CISH-STAT3
In summary, our study shows that iPSC-sEVs effectively rejuvenate senescent NK cells by partially suppressing CISH expression and promoting STAT3 phosphorylation. As a cell-free therapeutic agent, iPSC-sEVs represent a promising strategy for treating cancer in the elderly and other inflammatory senescence-related diseases.
Authors
- Lei Luo (ORCID: https://orcid.org/0000-0001-6191-6045)
- Shuxiang Yu
- Yu Chen (ORCID: https://orcid.org/0000-0002-9661-3914)
- Qing Li (ORCID: https://orcid.org/0009-0008-1770-7623)
- Juntao Zhang (ORCID: https://orcid.org/0000-0002-1591-4150)
- Yang Wang (ORCID: https://orcid.org/0000-0002-6649-5291)
- Zhengsheng Chen (ORCID: https://orcid.org/0000-0003-0628-3470)
- Xin Niu
- Rongrong Cao (ORCID: https://orcid.org/0000-0001-8760-8577)
- Ji Yuan (ORCID: https://orcid.org/0000-0002-4454-9105)
- Yajing Ren
Institutions
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13287-025-04761-0
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00