The effect of intracerebroventricular injection of insulin-like growth factor-1 on morphine-induced conditioned place preference extinction and reinstatement; a behavioral and biochemical experimental study
This study demonstrates that IGF-1 administration could facilitates the extinction and attenuate the reinstatement of morphine-induced CPP, highlighting its potential as a therapeutic strategy in opioid addiction.
Authors
- Shadi Shiva
- Ali Siahposht-Khachaki (ORCID: https://orcid.org/0000-0001-7505-3148)
- Erfan Ghadirzadeh (ORCID: https://orcid.org/0000-0002-3903-0464)
- Mobina Gheibi (ORCID: https://orcid.org/0000-0002-4092-8343)
- Ali Abdolkarimi
- Ehsan Vahdati Helan
- Mohammad Farvardin
Institutions
- Tabriz University of Medical Sciences (IR)
- Mazandaran University of Medical Sciences (IR)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12993-025-00304-y
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00