Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration

Regional centile scores derived from an extensive normative dataset represent a generalizable method for objectively identifying atrophy in neurodegenerative diseases and can be applied to determine neurodegenerative atrophy at the individual level.

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Publication Details

Journal
Alzheimer s Research & Therapy
Published
2025-11-12
DOI
https://doi.org/10.1186/s13195-025-01872-x
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
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article

Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration

Magdalena Kolanko, Niall Bourke, Joshua D. Bernstock, Richard A. I. Bethlehem et al.
Alzheimer s Research & Therapy
Parkinson's Disease Mechanisms and Treatments
article

Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration

Magdalena Kolanko, Niall Bourke, Joshua D. Bernstock, Richard A. I. Bethlehem, Aaron F. Alexander‐Bloch, Ethan J. F. Losty, Meera Srikrishna, John Kornak, Paresh Malhotra, Gregory Scott, Simon Richard White, Howard Rosen, Thomas D. Parker, David Sharp, Bruce L. Miller, Martina Del Giovane, Karl Zimmerman, Jakob Seidlitz, Michael David, David S. Knopman, Maria Luisa Mandelli, Jessica Hain, William W. Seeley, Michael Schöll, Neil Graham, Lena Dorfschmidt, Bradford Clark Dickerson, Maneesh C. Patel, Kimoko Domoto-Reilly, Adam L. Boxer, Anastasia Gailly de Taurines, Edward T. Bullmore, Scott McGinnis, Maria‐Luisa Gorno‐Tempini, Bradley F. Boeve
article en

Abstract

Regional centile scores derived from an extensive normative dataset represent a generalizable method for objectively identifying atrophy in neurodegenerative diseases and can be applied to determine neurodegenerative atrophy at the individual level.

Alzheimer s Research & TherapyVol. 17(1)
Brigham and Women's Hospital (US), Children's Hospital of Philadelphia (US), Harvard University (US), King's College London (GB), University of Cambridge (GB), Sahlgrenska University Hospital (SE), Hammersmith Hospital (GB), Charing Cross Hospital (GB), UK Dementia Research Institute (GB), MRC Biostatistics Unit (GB), NIHR Queen Square Dementia Biomedical Research Unit (GB), University College London (GB), Massachusetts Institute of Technology (US), University of Pennsylvania (US), University of Gothenburg (SE)
Openalex Percentile: Top 53%
Parkinson's Disease Mechanisms and Treatments
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