Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration
Regional centile scores derived from an extensive normative dataset represent a generalizable method for objectively identifying atrophy in neurodegenerative diseases and can be applied to determine neurodegenerative atrophy at the individual level.
Authors
- Magdalena Kolanko (ORCID: https://orcid.org/0000-0002-0058-5884)
- Niall Bourke (ORCID: https://orcid.org/0000-0001-6478-1430)
- Joshua D. Bernstock (ORCID: https://orcid.org/0000-0002-7814-3867)
- Richard A. I. Bethlehem (ORCID: https://orcid.org/0000-0002-0714-0685)
- Aaron F. Alexander‐Bloch (ORCID: https://orcid.org/0000-0001-6554-1893)
- Ethan J. F. Losty
- Meera Srikrishna (ORCID: https://orcid.org/0000-0002-5769-1653)
- John Kornak (ORCID: https://orcid.org/0000-0002-0089-0619)
- Paresh Malhotra (ORCID: https://orcid.org/0000-0002-1897-0780)
- Gregory Scott (ORCID: https://orcid.org/0000-0001-8063-5871)
- Simon Richard White (ORCID: https://orcid.org/0000-0001-8642-7037)
- Howard Rosen
- Thomas D. Parker (ORCID: https://orcid.org/0000-0001-7679-4220)
- David Sharp (ORCID: https://orcid.org/0000-0003-4995-2240)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Martina Del Giovane (ORCID: https://orcid.org/0000-0002-3476-8494)
- Karl Zimmerman (ORCID: https://orcid.org/0000-0003-1239-3414)
- Jakob Seidlitz (ORCID: https://orcid.org/0000-0002-8164-7476)
- Michael David (ORCID: https://orcid.org/0000-0002-8724-2840)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Maria Luisa Mandelli (ORCID: https://orcid.org/0000-0002-2518-2520)
- Jessica Hain (ORCID: https://orcid.org/0000-0002-5534-6418)
- William W. Seeley (ORCID: https://orcid.org/0000-0003-1410-2027)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Neil Graham (ORCID: https://orcid.org/0000-0002-0183-3368)
- Lena Dorfschmidt (ORCID: https://orcid.org/0000-0002-0447-1104)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Maneesh C. Patel
- Kimoko Domoto-Reilly
- Adam L. Boxer
- Anastasia Gailly de Taurines
- Edward T. Bullmore
- Scott McGinnis
- Maria‐Luisa Gorno‐Tempini
- Bradley F. Boeve
Institutions
- Brigham and Women's Hospital (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- King's College London (GB)
- University of Cambridge (GB)
- Sahlgrenska University Hospital (SE)
- Hammersmith Hospital (GB)
- Charing Cross Hospital (GB)
- UK Dementia Research Institute (GB)
- MRC Biostatistics Unit (GB)
- NIHR Queen Square Dementia Biomedical Research Unit (GB)
- University College London (GB)
- Massachusetts Institute of Technology (US)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s13195-025-01872-x
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00