Association of cesarean section with asthma and atopic dermatitis in infants from the Japan Environment and Children’s Study
Recently, the rates of allergic diseases and cesarean delivery have increased worldwide. Some reports describe associations between allergic diseases and cesarean delivery. However, the association between allergic diseases and cesarean delivery is controversial. In this study, we investigated the association between cesarean delivery and the development of wheezing and eczema among infants at 1 year of age. We used data including those of 104,065 fetal records and their children from the Japan Environment and Children's Study. Information about the mode of delivery, wheezing, eczema, asthma, and atopic dermatitis was obtained from medical record transcripts and questionnaires. Multiple logistic regression analysis was performed to determine the risks of wheezing, eczema, asthma, and atopic dermatitis among infants at 1 year of age associated with cesarean delivery. We included 74,639 subjects in this study, wherein 18.4% underwent cesarean deliveries. Children born by cesarean delivery had no increased odds of developing wheezing (adjusted odds ratio [aOR] = 0.98; 95% confidence intervals [CI, 0.93-1.04], eczema (aOR = 0.99; 95% CI, 0.94-1.05), asthma (aOR = 0.95; 95% CI, 0.84-1.08), or atopic dermatitis (aOR = 1.02; 95% CI, 0.92-1.13).
Authors
- Hyo Kyozuka (ORCID: https://orcid.org/0000-0001-7782-3396)
- Hayato Go (ORCID: https://orcid.org/0000-0002-0138-6676)
- Koichi Hashimoto (ORCID: https://orcid.org/0000-0001-8474-6456)
- Hidekazu Nishigori (ORCID: https://orcid.org/0000-0001-6726-2193)
- Hidekuni Inadera (ORCID: https://orcid.org/0000-0002-3548-221X)
- Ryo Kawasaki (ORCID: https://orcid.org/0000-0002-7492-6303)
- Hajime Iwasa (ORCID: https://orcid.org/0000-0003-2680-7366)
- Reiko Kishi
- Chisato Mori (ORCID: https://orcid.org/0000-0002-1144-8316)
- Seiji Yasumura (ORCID: https://orcid.org/0000-0002-4715-2840)
- Takahiko Katoh
- Yuka Ogata (ORCID: https://orcid.org/0009-0008-4827-4381)
- Mitsuaki Hosoya
- Hajime Maeda
- Narufumi Suganuma (ORCID: https://orcid.org/0000-0003-1610-6216)
- Shuichi Ito (ORCID: https://orcid.org/0000-0002-5242-8987)
- Seiji Kageyama (ORCID: https://orcid.org/0000-0002-5220-6137)
- Takeo Nakayama
- Maki Fukami (ORCID: https://orcid.org/0000-0001-9971-4035)
- Michihiro Kamijima (ORCID: https://orcid.org/0000-0003-0670-8790)
- Keiya Fujimori (ORCID: https://orcid.org/0000-0001-8618-4063)
- Yasuhiro Takeshima (ORCID: https://orcid.org/0000-0002-6468-7185)
- Chiharu Ota (ORCID: https://orcid.org/0000-0002-0644-1144)
- Kosei Shinoki
- Tsuyoshi Murata (ORCID: https://orcid.org/0000-0001-9506-117X)
- Shoichi Ohga
- Ryoji Shinohara (ORCID: https://orcid.org/0000-0003-1791-4119)
- Akiko Satô (ORCID: https://orcid.org/0000-0002-1279-4026)
- Shin Yamazaki (ORCID: https://orcid.org/0000-0002-2309-2425)
Institutions
- Fukushima Medical University (JP)
- Kyushu University (JP)
- Chiba University (JP)
- National Institute for Environmental Studies (JP)
- Tohoku University (JP)
- Hokkaido University (JP)
- Kyoto University (JP)
- Nagoya City University (JP)
- Tottori University Hospital (JP)
- Fukushima Prefectural Culture Center (JP)
- National Center For Child Health and Development (JP)
- University of Toyama (JP)
- University of Yamanashi (JP)
- Kōchi University (JP)
- Hyogo University (JP)
- Yokohama City University (JP)
- Kumamoto University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1038/s41598-025-23252-z
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Child Health and Development
- University of Occupational and Environmental Health
- Hyogo College of Medicine
- Hokkaido University
- Chiba University
- Nagoya City University