Why is your separase such a big protease?

Recent structural work explains a fundamental event during cell division, the timely and specific cleavage of the chromosomal cohesin complex by the protease separase.

Authors

Frank Uhlmann (ORCID: https://orcid.org/0000-0002-3527-6619)
Céline Bouchoux (ORCID: https://orcid.org/0000-0001-5064-4718)

Institutions

The Francis Crick Institute (GB)

Publication Details

Journal: Science Advances
Published: 2025-11-12
DOI: https://doi.org/10.1126/sciadv.aec7431
Primary Topic: Ubiquitin and proteasome pathways
Type: article
Field-Weighted Citation Impact: 0.00

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article

Why is your separase such a big protease?

Frank Uhlmann, Céline Bouchoux

Nov 12, 2025

Science Advances

Ubiquitin and proteasome pathways

article

Why is your separase such a big protease?

Frank Uhlmann, Céline Bouchoux

November 12, 2025article en

Abstract

Recent structural work explains a fundamental event during cell division, the timely and specific cleavage of the chromosomal cohesin complex by the protease separase.

Science AdvancesVol. 11(46)

The Francis Crick Institute (GB)

Openalex Percentile: Top 69%

Ubiquitin and proteasome pathways

DOI Open Access PDF OpenAlex

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Why is your separase such a big protease? — Frank Uhlmann, Céline Bouchoux · Science Advances (2025) | TGRS Research Map | TGRS