Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion
These findings underscore the crucial role of rhTB4 in mitigating cardiac dysfunction in an ErbB2-dependent manner. The clinical relevance of rhTB4 is demonstrated through a randomized controlled trial, emphasizing its translational potential. Further rigorous randomized studies are needed to assess the significance of early rhTB4 use post-myocardial infarction reperfusion.
Authors
- Ning Yang (ORCID: https://orcid.org/0009-0000-6667-2019)
- Bin Yang (ORCID: https://orcid.org/0000-0001-7689-5793)
- Chao Wu (ORCID: https://orcid.org/0000-0001-5546-410X)
- Lei Jia (ORCID: https://orcid.org/0000-0003-3721-1998)
- Qiuting Dong
- Rui Fu
- Xiaohui Bian (ORCID: https://orcid.org/0000-0002-9961-9668)
- Yuze Zhang (ORCID: https://orcid.org/0000-0002-5869-2033)
- 正 石橋 (ORCID: https://orcid.org/0000-0003-0103-2576)
- Kefei Dou (ORCID: https://orcid.org/0000-0002-8372-6338)
- Xinwei Jia
- Dong Yin
- Jincan Liu (ORCID: https://orcid.org/0000-0003-0044-7796)
- Fan Liu (ORCID: https://orcid.org/0000-0001-9241-8161)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-6990-5324)
- Yang Li (ORCID: https://orcid.org/0000-0002-0325-3199)
- Jingping Wang (ORCID: https://orcid.org/0000-0001-8079-5939)
- Chuanyu Gao (ORCID: https://orcid.org/0000-0002-7319-055X)
- Jincheng Guo (ORCID: https://orcid.org/0000-0001-6173-6386)
- Wenhua Lin (ORCID: https://orcid.org/0000-0002-0145-1677)
- Jiamao Fan (ORCID: https://orcid.org/0009-0008-5572-7350)
- Yi He (ORCID: https://orcid.org/0000-0003-3014-5211)
- Chuan-Jue Cui
- Ming Bai
- Chengquan Han
Institutions
- Hebei Medical University (CN)
- Shanxi Medical University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- TEDA International Cardiovascular Hospital (CN)
- Sinovac Biotech (CN)
- Xian Central Hospital (CN)
- Second Hospital of Hebei Medical University (CN)
- Beijing Luhe Hospital Affiliated to Capital Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Zhengzhou Central Hospital (CN)
- Affiliated Hospital of Hebei University (CN)
- Xian Yang Central Hospital (CN)
- Beijing Friendship Hospital (CN)
- Fu Wai Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Shanxi Cardiovascular Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1093/cvr/cvaf223
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00