Optimal adherence thresholds for oral anticoagulants in patients with atrial fibrillation using machine learning and population administrative data
Optimal adherence thresholds are higher than conventionally assumed and, especially for DOACs, are strongly associated with clinical outcomes. These results provide a basis for considering updating the definition of OAC nonadherence to PDC <0.9 for DOACs and to PDC <0.9 or <0.95 for VKAs, depending on the outcome.
Authors
- Marc W. Deyell (ORCID: https://orcid.org/0000-0001-8434-7076)
- Shahrzad Salmasi (ORCID: https://orcid.org/0000-0003-1330-3388)
- Mary A. De Vera (ORCID: https://orcid.org/0000-0002-2205-2683)
- Abdollah Safari (ORCID: https://orcid.org/0000-0001-9715-3086)
- Mina Tadrous (ORCID: https://orcid.org/0000-0003-1911-6129)
- Peter Loewen (ORCID: https://orcid.org/0000-0001-7160-6438)
- Adenike Adelakun (ORCID: https://orcid.org/0000-0003-1486-2392)
- Kristian B. Filion (ORCID: https://orcid.org/0000-0001-6055-0088)
- Jason G. Andrade (ORCID: https://orcid.org/0000-0002-8493-5123)
- Hamed Helisaz (ORCID: https://orcid.org/0000-0001-7739-1407)
Institutions
- Providence Health Care (CA)
- University of British Columbia (CA)
- University of Tehran (IR)
- Montreal Heart Institute (CA)
- Women's College Hospital (CA)
- Jewish General Hospital (CA)
- Centre for Advancing Health Outcomes (CA)
- McGill University (CA)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.jtha.2025.10.031
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00