<scp>SIRT5</scp> Facilitates Liver Steatosis Progression via Promoting <scp>SDH</scp> Desuccinylation During High‐Fat Diet Feeding
Our findings underscore the critical role of SIRT5 in the progress of liver steatosis and provide novel insights into the regulation of SDH by SIRT5-mediated desuccinylation that affects mitochondrial function. Moreover, our results suggest that targeting SIRT5 may offer a therapeutic strategy for liver steatosis.
Authors
- Qizhou Jiang
- Ruiyan Li (ORCID: https://orcid.org/0000-0001-5638-9914)
- Shilin Jia (ORCID: https://orcid.org/0000-0002-6715-9935)
- Junmei Ye (ORCID: https://orcid.org/0000-0003-1162-0216)
- Mengmeng Bao
- Chuang Ge (ORCID: https://orcid.org/0000-0002-0030-0674)
- Fei Xiao (ORCID: https://orcid.org/0000-0001-5262-2475)
- Xiaoying Xu (ORCID: https://orcid.org/0000-0001-8914-5262)
- Fangrong Yan (ORCID: https://orcid.org/0000-0003-3347-5021)
- Zekun Liu (ORCID: https://orcid.org/0000-0001-8690-8850)
- Mengjie Liu (ORCID: https://orcid.org/0009-0006-7823-1222)
- Yating Li (ORCID: https://orcid.org/0000-0002-7768-7264)
- Yuru Shao
- Jie Hu (ORCID: https://orcid.org/0000-0003-2605-7120)
- Yuan Lin (ORCID: https://orcid.org/0000-0002-8544-9995)
Institutions
- China Pharmaceutical University (CN)
- Wuhan Puai Hospital (CN)
Publication Details
- Journal
- Liver International
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1111/liv.70433
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions