The Imbalanced Patterns and Clinical Significance of Cytokines in Acute Myeloid Leukemia Microenvironment
The imbalanced patterns of cytokines were observed in both AML mice and AML patients. Interestingly, 3 cytokines (CCL3, CCL4 and CXCL10) were related to the outcome of AML patients, suggesting they are valuable for AML prognosis. Furthermore, the change of leukocyte subpopulations, either as causes or as consequences, may partially account for the change of cytokines in AML condition.
Authors
- Guoguang Zheng (ORCID: https://orcid.org/0000-0002-0829-3501)
- Keying Jing
- Rong Wang (ORCID: https://orcid.org/0000-0002-9303-4714)
- Huijuan Zhao (ORCID: https://orcid.org/0000-0001-6738-1141)
- Jun Cai (ORCID: https://orcid.org/0009-0001-5249-5805)
Institutions
- Henan University of Science and Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Henan Provincial People's Hospital (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/iid3.70290
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China