Sensing danger at the bridge

NoCut safeguards genome integrity against persistent DNA bridges, but how these missegregation events are sensed is not understood. In this issue, Dam et al. (https://doi.org/10.1083/jcb.202502014) identify the Srs2 and PARI helicases as conserved NoCut sensors that initiate signalling to delay cytokinetic abscission.

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Publication Details

Journal
The Journal of Cell Biology
Published
2025-11-12
DOI
https://doi.org/10.1083/jcb.202509237
Primary Topic
DNA Repair Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Sensing danger at the bridge

Juan Martin‐Serrano
The Journal of Cell Biology
DNA Repair Mechanisms
article

Sensing danger at the bridge

Juan Martin‐Serrano
article en

Abstract

NoCut safeguards genome integrity against persistent DNA bridges, but how these missegregation events are sensed is not understood. In this issue, Dam et al. (https://doi.org/10.1083/jcb.202502014) identify the Srs2 and PARI helicases as conserved NoCut sensors that initiate signalling to delay cytokinetic abscission.

The Journal of Cell BiologyVol. 224(12)
King's College - North Carolina (US), King's College London (GB)
Directorate for Biological Sciences
Openalex Percentile: Top 69%
DNA Repair Mechanisms
DOIOpen Access PDFOpenAlex
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Sensing danger at the bridge — Juan Martin‐Serrano · The Journal of Cell Biology (2025) | TGRS Research Map | TGRS