<i>MicroRNA-26b−/−</i> augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis
Overall, our results clearly demonstrate an atheroprotective role of miR-26b by attenuating lesion formation, mainly by suppressing inflammation and stimulating collagen breakdown. Furthermore, the therapeutic potential of miR-26b mimic-loaded LNPs could be proven, opening up new avenues for miRNA-based treatment options in the future.
Authors
- Sai Sahana Sundararaman (ORCID: https://orcid.org/0000-0001-8679-2819)
- Linsey J. F. Peters (ORCID: https://orcid.org/0009-0009-3657-9441)
- Baixue Yu
- Erik A.L. Biessen (ORCID: https://orcid.org/0000-0002-6454-8548)
- Marion J. Gijbels (ORCID: https://orcid.org/0000-0002-4906-0384)
- Alexander Jans (ORCID: https://orcid.org/0000-0002-2622-4278)
- Emiel P. C. van der Vorst (ORCID: https://orcid.org/0000-0001-5771-6278)
- Markus Haberbosch
- Kiril Bidzhekov
- Cheng Lin (ORCID: https://orcid.org/0009-0007-2326-1536)
- Matthias Bartneck (ORCID: https://orcid.org/0000-0003-1516-9610)
- Andrea Bonnin-Marquez
- Judith C. Sluimer (ORCID: https://orcid.org/0000-0002-0269-4582)
- Yvonne Jansen (ORCID: https://orcid.org/0000-0002-1283-8260)
- Yvonne Döring (ORCID: https://orcid.org/0000-0001-9307-3396)
- Kathrin Abschlag
- Sanne L. Maas (ORCID: https://orcid.org/0000-0003-1423-8901)
- Joachim Jankowski (ORCID: https://orcid.org/0000-0002-4528-2967)
- Rosanna Huchzermeier
- Christian Weber (ORCID: https://orcid.org/0000-0003-4610-8714)
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
- Maastricht University Medical Centre (NL)
- University Hospital of Bern (CH)
- Maastricht University (NL)
- Institute for Sports Medicine (DE)
- DWI – Leibniz Institute for Interactive Materials (DE)
- Amsterdam Neuroscience (NL)
- Munich Cluster for Systems Neurology (DE)
- Universitätsklinikum Aachen (DE)
- German Centre for Cardiovascular Research (DE)
- Institute of Infection and Immunity (CA)
- Ludwig-Maximilians-Universität München (DE)
- University of Amsterdam (NL)
- RWTH Aachen University (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1093/cvr/cvaf234
- Citations
- 3
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Corona-Stiftung
- Deutsche Forschungsgemeinschaft
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- RWTH Aachen University