INHALE-1: A Multicenter Randomized Trial of Inhaled Technosphere Insulin in Children With Type 1 Diabetes
The primary analysis did not meet the prespecified criteria for HbA1c noninferiority. However, TI use was safe over 26 weeks without affecting pulmonary function and was associated with greater treatment satisfaction and less weight gain compared with RAA, supporting TI as a treatment option for some pediatric patients with type 1 diabetes.
Authors
- Nicole Reese
- Kayla E. Wagner (ORCID: https://orcid.org/0000-0001-5008-9670)
- Faisal Malik (ORCID: https://orcid.org/0000-0002-2543-4214)
- Lezzan Keskin
- Dorothy I. Shulman (ORCID: https://orcid.org/0000-0002-5430-6916)
- Beth Pappenfus
- Janet Rodríguez
- Carrie Gregory (ORCID: https://orcid.org/0000-0003-3926-9288)
- Debra L. Miller (ORCID: https://orcid.org/0000-0002-8544-174X)
- Melanie Christian
- David P. Sparling (ORCID: https://orcid.org/0000-0001-5940-1544)
- Hannah Desrochers
- Janice Leschyshyn
- Robin Nemery
- Roshanak Monzavi (ORCID: https://orcid.org/0000-0002-0523-8726)
- Michael A. Wood (ORCID: https://orcid.org/0000-0003-2111-2063)
- Ulhas Nadgir
- Dhruva Patel
- Jamie Wood (ORCID: https://orcid.org/0000-0003-3172-0863)
- Shylaja Srinivasan (ORCID: https://orcid.org/0000-0002-8049-6370)
- Hung V. Le (ORCID: https://orcid.org/0009-0008-2219-8392)
- M. Patel (ORCID: https://orcid.org/0000-0001-8383-1931)
- Heather P. Harding (ORCID: https://orcid.org/0000-0002-7359-7974)
- M. Mack (ORCID: https://orcid.org/0000-0002-3489-9777)
- Stéphanie Woerner
- Antoinette Moran (ORCID: https://orcid.org/0000-0002-2694-5147)
- Craig J. McClain (ORCID: https://orcid.org/0000-0002-7219-8939)
- Nancy Chang (ORCID: https://orcid.org/0000-0002-0149-4386)
- Kashyap Shah (ORCID: https://orcid.org/0000-0001-7884-1692)
- Amy Steffen
- Joni Beck (ORCID: https://orcid.org/0000-0003-3392-8983)
- Natalie Marlen
- Brittany Bruggeman (ORCID: https://orcid.org/0000-0002-5117-8031)
- Lisa Paglia
- Kristina Cossen
- Taylor Sullivan
- Maja Marinković (ORCID: https://orcid.org/0000-0001-8911-8010)
- Lauren Bauer (ORCID: https://orcid.org/0000-0002-0947-7652)
- Marcela Vargas Trujillo
- Kamille Janess (ORCID: https://orcid.org/0000-0001-5771-4133)
- Heidi Strayer
- Michelle Murphy (ORCID: https://orcid.org/0000-0001-5173-1717)
- Xiaomiao Lan‐Pidhainy
- Michelle M. Smith (ORCID: https://orcid.org/0000-0002-7580-8894)
- Brittany Machus
- C. B. Truong
- Steven M. Willi
- Kate Weyman
- Yenniffer Ávalos (ORCID: https://orcid.org/0000-0002-0450-8552)
- Surya N. Mulukutla (ORCID: https://orcid.org/0000-0002-0447-0638)
- E Doble
- Abha Choudhary (ORCID: https://orcid.org/0000-0002-8340-3168)
- Joshua W. Smith (ORCID: https://orcid.org/0000-0002-8636-8097)
- Kanika Shanker
- Eva Tsalikian (ORCID: https://orcid.org/0000-0003-3429-2796)
- Sarah Holloway
- Emily Montgomery (ORCID: https://orcid.org/0000-0003-1389-0586)
- Melinda Pierce (ORCID: https://orcid.org/0000-0002-9908-9409)
- Samantha Garcia Perez
- Risa M. Wolf (ORCID: https://orcid.org/0000-0001-7674-520X)
- Anuj Bhargava (ORCID: https://orcid.org/0000-0002-5961-6171)
- LaTonda Tyler
- Sarah A. MacLeish (ORCID: https://orcid.org/0000-0002-3181-2488)
- Bliss Magella
- Cintya Schweisberger (ORCID: https://orcid.org/0000-0002-8915-6700)
- Rosanna Fiallo‐Scharer (ORCID: https://orcid.org/0000-0002-8939-4784)
- Perrin C. White (ORCID: https://orcid.org/0000-0001-6262-0289)
- Melinda Zgorski
- Patrick C. Hanley (ORCID: https://orcid.org/0000-0003-4298-7555)
- Diane Biernacki
- Marie Fox (ORCID: https://orcid.org/0000-0001-7497-2070)
- Paulette Smith
- Erica Memoli
- Hannah Elsinghorst
- JENIECE ILKOWITZ (ORCID: https://orcid.org/0000-0002-5832-373X)
- Shannon Beasley
- Nicole Cagnina
- Scott M. Blackman (ORCID: https://orcid.org/0000-0002-4532-6421)
- Wendy Campbell
- Terri Casey
- Michelle Wu
- Jessica A. Thomas (ORCID: https://orcid.org/0000-0001-6245-6060)
- Susan D. Phillips (ORCID: https://orcid.org/0000-0003-2126-8914)
- Britney M. Ellisor
- Bryce Nelson (ORCID: https://orcid.org/0000-0003-2400-5415)
- Barry Reiner
- Samuel Engle
- Louise Ambler-Osborn
- Muna Sunni (ORCID: https://orcid.org/0000-0003-2273-3478)
- Dhwani Shah (ORCID: https://orcid.org/0000-0001-5859-6685)
- Asheesh K. Dewan
- Christine Boatright (ORCID: https://orcid.org/0000-0003-2277-8326)
- Chris Church (ORCID: https://orcid.org/0000-0003-1006-0632)
- Marla Hashiguchi
- Andrew Muir (ORCID: https://orcid.org/0000-0002-4581-9875)
- Linton Cuff
- Brooke Burnett
- Eda Cengiz (ORCID: https://orcid.org/0000-0001-7992-9506)
- Noor Alramahi
- Linda Anne DiMeglio (ORCID: https://orcid.org/0000-0002-8033-6078)
- Lucy D. Mastrandrea (ORCID: https://orcid.org/0000-0002-6031-0153)
- Thomas J. Mouse
- Nicole Sheanon (ORCID: https://orcid.org/0000-0003-1338-1052)
- Linda Weber
- Teresa Quattrin
- Lauren Kanapka (ORCID: https://orcid.org/0000-0003-4440-5168)
- Lauren Pankratz
- Jennifer Jurado
- Eric I. Felner (ORCID: https://orcid.org/0000-0002-6567-0123)
- Elvira Isganaitis (ORCID: https://orcid.org/0000-0003-3477-0305)
- Karen Willard‐Gallo (ORCID: https://orcid.org/0000-0002-1150-1295)
- Mary Gallagher (ORCID: https://orcid.org/0000-0002-5844-2309)
- Robin L. Gal (ORCID: https://orcid.org/0000-0002-9628-5383)
- Shannon Hall
- Sarah Hart-Unger
- Sarah Peeling
- Priya Prahalad (ORCID: https://orcid.org/0000-0002-3894-4344)
- Ana Cecília Ribeiro Cruz (ORCID: https://orcid.org/0000-0002-4607-9346)
- Ryan P. Brady (ORCID: https://orcid.org/0000-0002-3087-4919)
- Lynette Gonzalez
- Michelle Rivera-Vega
- Shannan Davis
- David A. Geller (ORCID: https://orcid.org/0000-0003-0735-1068)
- Beth Loots
- Kevin B. Kaiserman (ORCID: https://orcid.org/0000-0002-3215-4317)
- Asha Bonney (ORCID: https://orcid.org/0000-0003-3647-3902)
- Ron S. Newfield (ORCID: https://orcid.org/0000-0001-6274-8530)
- Michael J. Haller (ORCID: https://orcid.org/0000-0002-2803-1824)
- Catherine Berry (ORCID: https://orcid.org/0000-0001-6363-9387)
- Mark S. Kipnes
- Julia Zack
- Janet C. King
- Kashif Latif
- Mariya V. Melnik (ORCID: https://orcid.org/0000-0001-8800-4628)
- Brittany Lewis
- Nora Arrizon‐Ruiz
- Jane J. Kim (ORCID: https://orcid.org/0000-0002-0228-0128)
- Martha Taboada
- Jennifer Abuzzahab
- B Holden
- Lisa Norlander
- Nuria García de la Torre (ORCID: https://orcid.org/0000-0003-3546-9231)
- Mary Patterson
- Daniel Brimberry
- Heather Speer
- ILENIA BALISTRERI
- Terri Ryan
- Lital Reitblat
- Eliana Frank
- Juliana Austin (ORCID: https://orcid.org/0000-0001-7932-1795)
- Kelsye Howell
- Anna Cymbaluk
- Himala Kashmiri
- Dana Chatila
- Jennifer Kyllo
- Luis Cantu
- Kristin Sabanosh
- Laya Ekhlaspour (ORCID: https://orcid.org/0000-0002-3263-1419)
- Kimberly Garrett
- Paul McGuigan
- K. R. Reddy (ORCID: https://orcid.org/0000-0001-9696-6675)
- Menno A. Brink
- Gnanagurudasan Prakasam (ORCID: https://orcid.org/0000-0002-4865-7867)
- Hubert Hug
- Michelle Van Name (ORCID: https://orcid.org/0000-0001-7672-4230)
- Catriona M. Farrell (ORCID: https://orcid.org/0009-0007-0463-5862)
- Kupper A. Wintergerst
- Joanna Kramer
- U. Yun
- Lori M. Laffel (ORCID: https://orcid.org/0000-0002-9675-3001)
- Kathleen E. Bethin
- Paul Hiers (ORCID: https://orcid.org/0000-0003-1072-6000)
- Carla Demeterco‐Berggren (ORCID: https://orcid.org/0000-0002-1140-644X)
- Diana Olivos‐Stewart
- K. Wetzel
- Juana Gonzalez (ORCID: https://orcid.org/0000-0001-7933-7017)
- Andrea Schmitt (ORCID: https://orcid.org/0000-0002-5426-4023)
- Kerry Milaszewski
- Lee Bromberger
- N. de Jong
- Pamela Hedrick
- Angela Y. Lam
- Leo Sher (ORCID: https://orcid.org/0000-0002-7729-3222)
- Johanna Ulloa
- Heather Henry
- Roy W. Beck (ORCID: https://orcid.org/0000-0002-5194-8446)
- Miriam Cintrón
- Kelly Johnson (ORCID: https://orcid.org/0000-0002-8738-4443)
- Helen Landers
- D. F. Graham
- Chijioke Ikomi (ORCID: https://orcid.org/0000-0002-0630-2355)
- Michael Tansey (ORCID: https://orcid.org/0000-0002-8157-8423)
- Julie Coffey
- L. Perez (ORCID: https://orcid.org/0000-0003-2939-7753)
- Rebecca Wesch
- Stretton Young
- Amy Hatton
- Pantea Minnock
- Y. Molina
- Marie M. Gleason
- David M. Maahs (ORCID: https://orcid.org/0000-0002-4602-7909)
- Sarah Doll
- Colten Youngblood
- Laura M. Jacobsen (ORCID: https://orcid.org/0000-0002-5144-7836)
- Jennifer Pleitez
- Joseph Sylvan
- Amber Antich
- Emily Tabaczynski
- Jade Doolan
- Angela Chen (ORCID: https://orcid.org/0000-0002-2697-0385)
- Sara E. Watson (ORCID: https://orcid.org/0000-0003-4316-1632)
- C. Johnson (ORCID: https://orcid.org/0000-0002-1599-4453)
- Diana Martínez (ORCID: https://orcid.org/0000-0001-6435-5992)
- Melissa Louise Kelly (ORCID: https://orcid.org/0000-0002-7468-2812)
- Jonathan Williams
- Catherine Chang
- Christine Burke
- Marissa Erickson
- KAITLYN WITT
- Michael Gottschalk (ORCID: https://orcid.org/0000-0002-5214-9929)
- Timothy P. Foster (ORCID: https://orcid.org/0000-0002-4681-4558)
- Lori M. Laffel (ORCID: https://orcid.org/0000-0003-2202-492X)
- Kathy Fitzgerald
- Ramon Adams
- Katherine Dean
- Christine Langel
- Lynn Badgett
- Amanda M. House
- Emma Smith (ORCID: https://orcid.org/0000-0002-4206-5617)
- Tamara S. Hannon (ORCID: https://orcid.org/0000-0002-7523-5053)
- Matthew Kaufman
- Aishwarya Shivaji Mate
- G. Barry Pierce
- Dean A. Handley
- Christina R. Larson (ORCID: https://orcid.org/0009-0003-3215-5648)
- Janey Adams
- Larry Dolan
- Lissette S. Velasquez
- Heather Rush
- P. Hemphill
- Craig Kollman
- A. Bohr
- Jean Barton
- Michael J. Haller
- Chantal Nwosu
- C. Torres (ORCID: https://orcid.org/0009-0004-9504-9874)
- Nicholas J. Sears
- Jamie Thomas
- Mark A. Clements
- Bermudez Yudith Escobar
- Joshua Moyer
- Deanna Gabrielson
- Jimmy Penn
- Kara Turner
- A. Narayan
- Stephanie Beltran
- S Shah (ORCID: https://orcid.org/0000-0002-8109-5392)
- Henry Rodriguez
- Nikta Forghani
- M McFadden
- JASMINE Y. HOSSEINIPOUR
- Hunter Vallejo
- Holly Hemann
- Adrienne M. Casciato
- Faisal Malik (ORCID: https://orcid.org/0000-0002-9627-5433)
- Daniella Orpi
- Pamela Parcon
- Emma Bickfard
- Chanpreet Toor
- Veronica Jones-Carr
- Shannon Carper
- Mary McFeters
- Sheila Calumpiano
- Lesley Draffin
- Tayler Romprey
- Hannah Lease
- Brenden Teaman
- Alexandra LaCarte
- Paige Aossey
- Travis Boman
- Sara Agamaite
- Lisa Staples-Wherry
- Joshua Modeste
- Ciara DeGraff
- William Hibbard
- Jose David Gamez-Godoy
- Richard Dugan-Starr
- Alora Rumfola
- Brittany Powroznik
- Dawn Dziubek
- Victoria Mancillas
- Jerylen Caraecle
- Gregory Spires
- Lisa Kenigsberg Fetcher
- Jean “Yvener” Deverlis
- Lisa Kalnik
- Stephenie Yapchanyk
- Roberta Brunson
Institutions
- University of Mary (US)
- University of Iowa (US)
- Cincinnati Children's Hospital Medical Center (US)
- Joslin Diabetes Center (US)
- Center for Infectious Disease Research (US)
- University of Minnesota (US)
- Children's Hospital of Orange County (US)
- Alfred I. duPont Hospital for Children (US)
- Children's Mercy Hospital (US)
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- University of Indianapolis (US)
- Eastern Michigan University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, San Francisco (US)
- Virginia Commonwealth University (US)
- Medical College of Wisconsin (US)
- University of South Florida (US)
- University Hospitals of Cleveland (US)
- AdventHealth Orlando (US)
- Sutter Medical Center (US)
- Diabetes Australia (AU)
- Johns Hopkins Medicine (US)
- Pennsylvania Hospital (US)
- University of Minnesota System (US)
- Community Health Systems - Dupont Hospital (US)
- AdventHealth East Orlando (US)
- Hospital Research Foundation (AU)
- Yale University (US)
- University of Florida (US)
- University of New Haven (US)
- NYU Langone Health (US)
- Rady Children's Hospital-San Diego (US)
- Rio Grande Bible Institute (US)
- Mountain Home School District (US)
- Doctors Hospital at Renaissance (US)
- Ypsilanti District Library (US)
- Valley Medical Center (US)
- Nemours Children's Health System (US)
- Buffalo Medical Group (US)
- Seattle Children's Hospital (US)
- Yale New Haven Health System (US)
- Diabetes & Endocrinology Specialists (US)
- Diabetes & Glandular Disease Clinic (US)
- Norton Hospital (US)
- Jaeb Center for Health Research (US)
- Rocky Mountain Research Station (US)
- University of Louisville Hospital (US)
- Iowa Diabetes and Endocrinology Research Center (US)
- Johns Hopkins Hospital (US)
- Rocky Mountain Diabetes and Osteoporosis Center (US)
- Mercy Hospital (US)
- University of Oklahoma Health Sciences Center (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Baltimore (US)
- University at Buffalo, State University of New York (US)
- The University of Texas Southwestern Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-11-12
- DOI
- https://doi.org/10.2337/dc25-1994
- Citations
- 4
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 6.07