Long‐read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease
Long-read sequencing enables analysis of "dark" regions Alzheimer's disease brains Somatic AluY retrotransposon insertions may be elevated in late-stage disease Retrotransposon-associated non-allelic homologous recombination (NAHR) is enriched in repetitive regions in early disease DNA demethylation within the centro/pericentromere and ribosomal DNA (rDNA) occur across disease stage Dark regions of risk genes are differentially methylated across disease stage.
Authors
- Wenyan Sun (ORCID: https://orcid.org/0000-0002-3186-5002)
- Kevin F. Bieniek (ORCID: https://orcid.org/0000-0003-4922-864X)
- Bess Frost (ORCID: https://orcid.org/0000-0002-1212-8138)
- Giovanni Pascarella (ORCID: https://orcid.org/0000-0002-9225-0458)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- Habil Zare (ORCID: https://orcid.org/0000-0001-5902-6238)
- Piero Carninci (ORCID: https://orcid.org/0000-0001-7202-7243)
- Shiva Kazempour Dehkordi (ORCID: https://orcid.org/0000-0003-0349-4360)
- Paulino Ramirez (ORCID: https://orcid.org/0000-0001-8532-9590)
Institutions
- Tulane University (US)
- Texas A&M University – San Antonio (US)
- The University of Texas at San Antonio Health Science Center (US)
- Brown University (US)
- Longevity Biotech (United States) (US)
- Institute for Neurodegenerative Disorders (US)
- RIKEN Center for Integrative Medical Sciences (JP)
- The University of Texas at San Antonio (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70852
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- BrightFocus Foundation
- University of Texas at Austin
- National Institutes of Health
- Department of Mechanical Engineering, University of Texas at Austin
- University of California, Davis
- National Institute on Aging
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke
- Genome Center, University of California, Davis