Clinical characteristics and risk factors for <i>Clostridioides difficile</i> infection in the hematopoietic cell transplantation population

CDI is a common, early complication of HCT particularly among allogeneic recipients. Penicillin exposure, prior chemotherapy, and cord blood stem cell source are key risk factors, while macrolide use is associated with recurrence. Our findings highlight potential targets for risk-stratified prevention strategies.

Authors

Abhishek Deshpande (ORCID: https://orcid.org/0000-0001-5522-2995)
Joseph O’Brien (ORCID: https://orcid.org/0009-0006-9905-7139)
Matthew A. Pappas (ORCID: https://orcid.org/0000-0002-0353-1785)
Betty K. Hamilton (ORCID: https://orcid.org/0000-0003-1252-6539)

Institutions

Cleveland Clinic (US)
Walmart (United States) (US)
Walsh University (US)
Denver Health Medical Center (US)
Cleveland Clinic Lerner College of Medicine (US)
Case Western Reserve University (US)
University of Colorado Denver (US)

Publication Details

Journal: Infection Control and Hospital Epidemiology
Published: 2025-11-14
DOI: https://doi.org/10.1017/ice.2025.10330
Primary Topic: Clostridium difficile and Clostridium perfringens research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Clinical characteristics and risk factors for Clostridioides difficile infection in the hematopoietic cell transplantation population

Abhishek Deshpande, Joseph O’Brien, Matthew A. Pappas, Betty K. Hamilton

Nov 14, 2025

Infection Control and Hospital Epidemiology

Clostridium difficile and Clostridium perfringens research

article

Clinical characteristics and risk factors for Clostridioides difficile infection in the hematopoietic cell transplantation population

Abhishek Deshpande, Joseph O’Brien, Matthew A. Pappas, Betty K. Hamilton

November 14, 2025article en

Abstract

CDI is a common, early complication of HCT particularly among allogeneic recipients. Penicillin exposure, prior chemotherapy, and cord blood stem cell source are key risk factors, while macrolide use is associated with recurrence. Our findings highlight potential targets for risk-stratified prevention strategies.

Infection Control and Hospital EpidemiologyVol. 47(1)

Cleveland Clinic (US), Walmart (United States) (US), Walsh University (US), Denver Health Medical Center (US), Cleveland Clinic Lerner College of Medicine (US), Case Western Reserve University (US), University of Colorado Denver (US)

Openalex Percentile: Top 60%

Clostridium difficile and Clostridium perfringens research

DOI Source OpenAlex

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Clinical characteristics and risk factors for <i>Clostridioides difficile</i> infection in the hematopoietic cell transplantation population — Abhishek Deshpande, Joseph O’Brien, et al. · Infection Control and Hospital Epidemiology (2025) | TGRS Research Map | TGRS